Publications

2024

PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK

Thon O, Wang Z, Schmidpeter PA, Nimigean CM.

Nat Commun. 2024 Sep 19;15(1):8230. doi: 10.1038/s41467-024-52469-1

2023

Native Function of the Bacterial Ion Channel SthK in a Sparsely Tethered Lipid Bilayer Membrane Architecture

Andersson J, Kleinheinz D, Ramach U, Kiesenhofer N, Ashenden A, Valtiner M, Holt S, Koeper I, Schmidpeter PA, Knoll W. 

J Phys Chem B. 2023 Apr 27;127(16):3641-3650. doi: 10.1021/acs.jpcb.2c07252

Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel

Pan Y, Pohjolainen E, Schmidpeter PA, Vaiana AC, Nimigean CM, Grubmüller H, Scheuring S

Nat Struct Mol Biol. 2023 Mar 27. doi: 10.1038/s41594-023-00955-3

Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1

Schmidpeter PA, Petroff JT 2nd, Khajoueinejad L, Wague A, Frankfater C, Cheng WWL, Nimigean CM, Riegelhaupt PM

Nat Commun. 2023 Feb 25;14(1):1077. doi: 10.1038/s41467-023-36765-w

2022

Anionic lipids unlock the gates of select ion channels in the pacemaker family

Schmidpeter PA, Wu D, Rheinberger J, Riegelhaupt PM, Tang H, Robinson CV, Nimigean CM

Nat Struct Mol Biol. 2022 Nov;29(11):1092-1100. doi: 10.1038/s41594-022-00851-2

Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel

Gao X*, Schmidpeter PA*, Berka V, Durham RJ, Fan C, Jayaraman V, Nimigean CM

Nat Commun. 2022 Nov 14;13(1):6919. doi: 10.1038/s41467-022-34673-z

2021

Correlating ion channel structure and function

Schmidpeter PA, Nimigean CM

Methods Enzymol. 2021;652:3-30. doi: 10.1016/bs.mie.2021.02.016

2020

Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel

Schmidpeter PA, Rheinberger J, Nimigean CM

Nat Commun. 2020 Dec 16;11(1):6401. doi: 10.1038/s41467-020-20104-4

Reconstitution of Membrane Proteins into Platforms Suitable for Biophysical and Structural Analyses.

Schmidpeter PA, Sukomon N, Nimigean CM

Methods Mol Biol. 2020;2127:191-205. doi: 10.1007/978-1-0716-0373-4_14

2019

Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel

Tong A, Petroff JT 2nd, Hsu FF, Schmidpeter PA, Nimigean CM, Sharp L, Brannigan G, Cheng WWL

Elife. 2019 Nov 14;8. doi: 10.7554/eLife.50766

2018

Fluorescence Titrations to Determine the Binding Affinity of Cyclic Nucleotides to SthK Ion Channels

Schmidpeter PA, Nimigean CM

Bio Protoc. 2018 Oct 5;8(19). doi: 10.21769/BioProtoc.3041

Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures

Rheinberger J, Gao X, Schmidpeter PA, Nimigean CM

Elife. 2018 Jul 20;7. doi: 10.7554/eLife.39775

Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK

Schmidpeter PA*, Gao X*, Uphadyay V, Rheinberger J, Nimigean CM

J Gen Physiol. 2018 Jun 4;150(6):821-834. doi: 10.1085/jgp.201812023

2017

Identification of a pre-active conformation of a pentameric channel receptor

Menny A, Lefebvre SN, Schmidpeter PA, Drège E, Fourati Z, Delarue M, Edelstein SJ, Nimigean CM, Joseph D, Corringer PJ

Elife. 2017 Mar 15;6. doi: 10.7554/eLife.23955

Dynamics of Aromatic Side Chains in the Active Site of FKBP12

Weininger U, Modig K, Geitner AJ, Schmidpeter PA, Koch JR, Akke M

Biochemistry. 2017 Jan 10;56(1):334-343. doi: 10.1021/acs.biochem.6b01157

2016

Incorporation of an Unnatural Amino Acid as a Domain-Specific Fluorescence Probe in a Two-Domain Protein

Ries LK, Schmid FX, Schmidpeter PA

Biochemistry. 2016 Dec 13;55(49):6739-6742. doi: 10.1021/acs.biochem.6b00898

Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps

Jakob RP, Schmidpeter PA, Koch JR, Schmid FX, Maier T

PLoS One. 2016;11(6):e0157070. doi: 10.1371/journal.pone.0157070. eCollection 2016

2015

Long-Range Energetic Changes Triggered by a Proline Switch in the Signal Adapter Protein c-CrkII

Schmidpeter PA, Ries LK, Theer T, Schmid FX

J Mol Biol. 2015 Dec 4;427(24):3908-20. doi: 10.1016/j.jmb.2015.09.028

Control of protein function by prolyl isomerization

Schmidpeter PA, Koch JR, Schmid FX

Biochim Biophys Acta. 2015 Oct;1850(10):1973-82. doi: 10.1016/j.bbagen.2014.12.019

Functional adaptations of the bacterial chaperone trigger factor to extreme environmental temperatures

Godin-Roulling A*, Schmidpeter PA*, Schmid FX, Feller G

Environ Microbiol. 2015 Jul;17(7):2407-20. doi: 10.1111/1462-2920.12707

Prolyl isomerization and its catalysis in protein folding and protein function

Schmidpeter PA, Schmid FX

J Mol Biol. 2015 Apr 10;427(7):1609-31. doi: 10.1016/j.jmb.2015.01.023

Dimeric Structure of the Bacterial Extracellular Foldase PrsA

Jakob RP, Koch JR, Burmann BM, Schmidpeter PA, Hunkeler M, Hiller S, Schmid FX, Maier T

J Biol Chem. 2015 Feb 6;290(6):3278-92. doi: 10.1074/jbc.M114.622910

Prolyl isomerization as a molecular memory in the allosteric regulation of the signal adapter protein c-CrkII

Schmidpeter PA, Schmid FX

J Biol Chem. 2015 Jan 30;290(5):3021-32. doi: 10.1074/jbc.M114.617308

2014

Phosphorylation and prolyl isomerization independently regulate the signal adapter function of CrkII

Schmidpeter PA, Schmid FX

J Mol Biol. 2014 Dec 12;426(24):3929-3934. doi: 10.1016/j.jmb.2014.09.022

Molecular determinants of a regulatory prolyl isomerization in the signal adapter protein c-CrkII

Schmidpeter PA, Schmid FX

ACS Chem Biol. 2014 May 16;9(5):1145-52. doi: 10.1021/cb500001n

2013

Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency

Feiler C, Fisher AC, Boock JT, Marrichi MJ, Wright L, Schmidpeter PA, Blankenfeldt W, Pavelka M, DeLisa MP

PLoS One. 2013;8(9):e73123. doi: 10.1371/journal.pone.0073123

2011

Prolyl isomerases show low sequence specificity toward the residue following the proline

Schmidpeter PA, Jahreis G, Geitner AJ, Schmid FX

Biochemistry. 2011 May 31;50(21):4796-803. doi: 10.1021/bi200442q

Copyright © 2023 Philipp Schmidpeter